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Clinical findings on the use of Sinomarin®:
1. Freche et al., “Usefulness of hypertonic seawater (Sinomarin®) in rhinology. Revue Officielle de la Societe Francaise de
ORL, 50(4), 1998.
Open clinical multicentre study conducted in France on 80
adults with nasal disorders that caused permanent or
intermittent nasal obstruction.
Evaluation of Nasal Obstruction
• Complete disappearance 19,8%
• Improvement 57,7%
• Stabilization 21,1%
• Aggravation 1,4%
After 2 weeks of treatment, 2 applications per day, a
significant improvement or disappearance of symptoms was
observed in more than 75% of the cases!
Clinical Efficacy
• Significant improvement was observed in
most etiology of rhinitis cases
• 81% of all cases were rated as satisfactory or above
After two weeks of treatment, a significant improvement or
total disappearance of nasal obstruction was seen in 81%
of cases for most etiologies of rhinitis cases.
Safety and tolerance
95% of the people who used Sinomarin report good or excellent tolerance!
“Use of hypertonic seawater (2.3%) is effective on nasal
obstruction (hypertrophic rhinitis, allergic rhinitis,
polyposis, vasomotor rhinitis, purulent rhinitis,
unspecified rhinitis”
2. Clinical study conducted in 2007 with Mexican patients:
an investigational, prospective, longitudinal,
comparative, multicentre, open-label study on the efficacy
and tolerability of Sinomarin Spray for the treatment of
rhinitis. Journal of the Federation of Otalaryngological and
Societies of the Mexican Republic, 2008.
Investigational, prospective, longitudinal, comparative,
multi-centre, open-label study conducted in Mexico on 333
patients assessing the efficacy and tolerance of Sinomarin
Spray for the treatment of rhinitis.
Evaluation of Nasal Obstruction
After 20 days of treatment, a significant improvement or
disappearance of symptoms was observed in Sinomarin-treated
patients.
Evaluation of rhinorrhea level
After 20 days of treatment, a significant improvement of
rhinorrhea was observed in Sinomarin-treated patients
(p<0.05)
Tolerance
Sinomarin was well tolerated in all cases: “The study demonstrates that hypertonic solution
irrigation using Sinomarin® (2.3%) is beneficial, since it
enables a more rapid action on the edema, a virtually
common characteristic of nasal, catarrhal, infectious or
allergic disorders.”
3. Süslü N, et. al. Effects of buffered 2.3%, buffered
0.9%, and non-buffered 0.9% irrigation solutions on nasal
mucosa after septoplasty. Eur Arch Otorhinolaryngol. 2009
May;266(5):685-9. Epub 2008 Sep 18.
Prospective randomized study comparing the effect of 2.3%
buffered hypertonic seawater with buffered isotonic saline
and non-buffered isotonic saline) on mucociliary clearance
and nasal patency in 45 patients who underwent septoplasty.
Saccharine Clearance Times (SCT) indicative of mucociliary clearance.
Hypertonic solutions are more advantageous than isotonic
solutions for use in MCT mucociliary clearance. Positive
effect of buffered 2.3% hypertonic seawater on the
mucociliary activity has been attributed to both its
alkalinity and high osmolarity.
Nasal patency increase on the 20th operative day with
respect to 5th postoperative day, showed significant
difference between the buffered 2.3% hypertonic saline
compared to non-buffered isotonic saline (P = 0.042).
“Buffered hypertonic solutions used after endonasal
surgery have been advantageous for both mucociliary
clearance and postoperative decongestion, and these
solutions do not cause severe nasal burning that prevents
their use.”
More Clinical findings on Hypertonic nasal solutions
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